Leptin deficiency enhances sensitivity to endotoxin-induced lethality

• DOI: 10.1152/ajpregu.1999.276.1.r136
• Publication Date: 2017-12-25T06:11:42Z
• Authors: Raffaella Faggioni; Giamila Fantuzzi; Cem Gabay; Arthur Moser; Charles A. Dinarello; Kenneth R. Feingold; Carl Grunfeld
• Keywords: Lethality

Leptin is induced by lipopolysaccharide (LPS) and cytokines. We investigated the role of leptin in LPS-induced toxicity using leptin-deficient ( ob/ ob) receptor-deficient db/ db) mice. Sensitivity to mortality significantly greater obmice compared with their own lean littermates but not dbmice. LPS reduced serum glucose both oband dbmice corticosterone only Despite very high basal levels dbmice, a twofold increase was observed after littermates. No differences were detected interleukin (IL)-1β, tumor necrosis factor, macrophage inflammatory protein-1α, interferon-γ In contrast, blunted induction IL-10 IL-1 receptor antagonist (IL-1Ra) vitro, IL-1Ra production upregulated macrophages. Moreover, treatment reversed increased sensitivity lethality found obmice. These results suggest that participates host response inflammation modulating immune cytokine responses LPS.