Central administration of the somatostatin analog octreotide induces captopril-insensitive sleep responses

• DOI: 10.1152/ajpregu.1999.277.5.r1297
• Publication Date: 2017-12-25T04:50:56Z
• Authors: L. Beranek; I. Hajdu; J. Gardi; P. Taishi; F. Obál; J. M. Krueger
• Keywords: Microgram; Captopril

The effects of intracerebroventricular injections the long-lasting somatostatin analog octreotide (Oct) were studied on sleep and behavior in rats. Pyrogen-free physiological saline Oct (0.001, 0.01, 0.1 μg) or vehicle administered at light onset, electroencephalogram (EEG), motor activity, cortical brain temperature recorded during 12-h period. Plasma growth hormone (GH) concentrations measured samples taken 30-min intervals after Oct. (0.01 suppressed non-rapid eye movement (NREMS) for 1–2 h. NREMS intensity (delta EEG activity NREMS) dose dependently increased hour 3 postinjection thereafter (0.1 μg). GH μg), but pulses secretions occurred 90–120 min each rat. enhanced behavioral including prompt drinking followed by grooming, scratching, feeding. Intracerebroventricular injection angiotensin-converting enzyme inhibitor captopril (30 μg, 10 before Oct), blocked these responses not Oct-induced alterations. changes suggest an intracerebral action site might result from variations sleep-promoting GH-releasing hormone.