Short-term and long-term blood pressure and heart rate variability in the mouse

• DOI: 10.1152/ajpregu.2000.278.1.r215
• Publication Date: 2017-12-25T04:43:05Z
• Authors: Ben J. A. Janssen; Peter J. A. Leenders; Jos F. M. Smits
• Keywords: Mean arterial pressure

Knowledge on murine blood pressure and heart rate control mechanisms is limited. With the use of a tethering system, mean arterial (MAP) pulse interval (PI) were continuously recorded for periods up to 3 wk in Swiss mice. The day-to-day variation MAP PI was stable from 5 days after surgery. Within each mouse (n = 9), varied by 21+/-6 mm Hg 17+/-4 ms around their respective 24-h averages (97+/-3 89+/-3 ms). Over periods, bimodally distributed clustered two preferential states. Short-term variability compared between resting (control) active states using spectral analysis. In conditions, mainly confined frequencies <1 Hz, whereas predominantly linked respiration cycle (3-6 Hz). state, power increased 0.08- 3-Hz range, fell 0.4-Hz range. both coherence high at 0.4 Hz with leading fluctuations 0.3-0.4 s, suggesting that reflex coupling occurred same frequency range as rats. studied intravenous injection autonomic blockers. Compared ganglionic blockade hexamethonium. Comparable responses obtained alpha-blocker prazosin, beta-blocker metoprolol similarly. Muscarinic atropine did not significantly alter steady-state levels PI. Both hexamethonium prazosin decreased 1-Hz contrast, metoprolol, 0.4- Atropine had no effect but those These data indicate that, mice, its are under sympathetic control, vagal nerves variability. Blockade endogenous nitric oxide formation N(G)-nitro-L-arginine methyl ester specifically role buffering fluctuations.