Commensal microbiota regulate aldosterone

• DOI: 10.1152/ajprenal.00051.2024
• Publication Date: 2024-04-18T08:01:51Z
• Authors: Brittni N. Moore; Alexandra D. Medcalf; Rachel Q. Muir; Chudan Xu; Francine Z. Marques; Jennifer L. Pluznick
• Keywords: Male; 0303 health sciences; Blood Pressure; Gastrointestinal Microbiome; Anti-Bacterial Agents; Mice, Inbred C57BL; Mice; 03 medical and health sciences; Renin; Hypertension; Animals; Germ-Free Life; Female; Aldosterone

We explore the role of the gut microbiome in regulating aldosterone, a hormone closely linked to blood pressure and cardiovascular disease. Despite the recognized importance of the gut microbiome in host physiology, the relationship with circulating aldosterone remains largely unexplored. We demonstrate that suppression of gut microbiota leads to increased levels of plasma and urinary aldosterone. These findings underscore the potential of the gut microbiota to influence aldosterone regulation, suggesting new possibilities for treating hypertension.