Heat acclimation ameliorated heat stress-induced acute kidney injury and prevented changes in kidney macrophages and fibrosis

• DOI: 10.1152/ajprenal.00065.2022
• Publication Date: 2022-07-07T11:56:27Z
• Authors: Hiroyasu Goto; Masahiro Nakashima; Hiroyuki Nakashima; Midori Noguchi; Toshihiko Imakiire; Naoki Oshima; Manabu Kinoshita; Hiroo Kumagai
• Keywords: Heatstroke; Proinflammatory cytokine

Heat stress could induce acute kidney injury. Although heat acclimation (HA) reportedly provides thermal tolerance, its effect on stress-induced damage remains unclear. This study showed that 5-day HA ameliorates mouse tubular and subsequent fibrosis caused by stress. It also demonstrated enhances intracellular shock protein 70 expression in cells prevents a decrease resident macrophages, which explains the renoprotective of HA.