Effect of high-frequency oscillation on lung lymph flow

• DOI: 10.1152/jappl.1983.55.5.1373
• Publication Date: 2017-12-25T05:21:23Z
• Authors: A. L. Jefferies; P. Hamilton; H. M. O'Brodovich
• Keywords: Positive-Pressure Respiration; Pulmonary Circulation; 03 medical and health sciences; Sheep; 0302 clinical medicine; Animals; Blood Pressure; Lymph; Pulmonary Wedge Pressure; Lung; Respiration, Artificial

We investigated the effect of high-frequency oscillation (HFO) on lung lymphatic function under normal conditions and when lymph flow was increased by air microembolization. In six experiments, sheep goats with chronic fistulas vascular catheters were anesthetized, paralyzed, intubated, ventilated according to following protocol: 1) intermittent positive-pressure ventilation (IPPV) for 1 h, 2) HFO a frequency 15 Hz an estimated tidal volume 1-2 ml/kg 3) IPPV 0.5 h. Ventilator settings adjusted maintain arterial Po2 above 100 Torr Pco2. Vascular, esophageal, mean airway pressures monitored continuously. Lymph cardiac output recorded every min. With this protocol, there no changes in pulmonary or esophageal pressures, remained stable throughout experiment. additional five microemboli infused approximately 30 min during HFO. Left atrial pressure unchanged tripled. This response qualitatively quantitatively similar that previously reported unanesthetized spontaneously breathing sheep. conclude does not impair resting lymphatics retain their ability increase water protein clearance