Effect of granulocyte depletion in a ventilated surfactant-depleted lung

• DOI: 10.1152/jappl.1987.62.1.27
• Publication Date: 2017-12-21T06:23:58Z
• Authors: T. Kawano; S. Mori; M. Cybulsky; R. Burger; A. Ballin; E. Cutz; A. C. Bryan
• Keywords: Lung Diseases; Pulmonary Gas Exchange; Pulmonary Surfactants; Respiration, Artificial; Epithelium; Leukocyte Count; 03 medical and health sciences; 0302 clinical medicine; Animals; Mechlorethamine; Rabbits; Granulocytes

In a previous paper Cutz, Bryan et al. showed that in rabbits after repetitive lung lavage high-frequency oscillatory ventilation maintained excellent gas exchange and did not cause hyaline membrane formation (J. Appl. Physiol. 55: 131–138, 1983). contrast, conventional mechanical had poor extensive we attributed these differences to barotrauma. However, completely overlooked the large number of granulocytes damaged lung. To investigate this using same model have used on two groups rabbits, one with normal granulocytes, other depleted by pretreatment nitrogen mustard. The nondepleted exchange, substantial protein leak into membranes. animals good very small no Repletion from donor lead formation. It is concluded causes prompt margination which become activated ongoing epithelial barotrauma ventilation.