Differing effects of anesthetics on splanchnic arterial blood flow during hemorrhagic shock

• DOI: 10.1152/jappl.1994.76.6.2304
• Publication Date: 2017-12-22T09:31:50Z
• Authors: S. I. Myers; R. Hernandez; T. A. Miller
• Keywords: Methoxyflurane

The effect of anesthesia on splanchnic blood flow was examined during hemorrhagic shock and resuscitation. Sprague-Dawley rats were anesthetized with the inhalation anesthetic, methoxyflurane, or pentobarbital (65 mg/kg). Transonic Doppler probes placed around superior mesenteric artery (SMA) abdominal aorta, animals subjected to acute hemorrhage (or sham) 30 mmHg for 90 min followed by resuscitation shed (n = 6/group). At 90, 105, 120 min, sham in both anesthetic groups showed comparable pressures a 50% decrease SMA aortic flow. Acute decreased 94.5 +/- 0.01 86.0 2.8%, respectively, methoxyflurane groups, similar changes occurring During resuscitation, arterial pressure remained significantly depressed 65% group, whereas returned control levels increased 56% values (P < 0.001) group. findings indicate that choice agent may impact needs be taken into account when designing experiments examining effects shock.