Chronically and acutely exercised rats: biomarkers of oxidative stress and endogenous antioxidants

• DOI: 10.1152/jappl.2000.89.1.21
• Publication Date: 2017-12-23T01:59:59Z
• Authors: Jiankang Liu; Helen C. Yeo; Eva Övervik-Douki; Tory Hagen; Stephanie J. Doniger; Daniel W. Chu; George A. Brooks; Bruce N. Ames
• Keywords: Malondialdehyde

The responses to oxidative stress induced by chronic exercise (8-wk treadmill running) or acute (treadmill running exhaustion) were investigated in the brain, liver, heart, kidney, and muscles of rats. Various biomarkers measured, namely, lipid peroxidation [malondialdehyde (MDA)], protein oxidation (protein carbonyl levels glutamine synthetase activity), DNA damage (8-hydroxy-2′-deoxyguanosine), endogenous antioxidants (ascorbic acid, α-tocopherol, glutathione, ubiquinone, ubiquinol, cysteine). predominant changes are MDA, ascorbic cysteine, cystine. mitochondrial fraction brain liver showed as assayed MDA similar those tissue homogenate. Our results show that quite different from fast muscle, slow muscle; elicits depending on organ type its antioxidant levels.