Glutamine induces heat shock protein and protects against endotoxin shock in the rat

• DOI: 10.1152/jappl.2001.90.6.2403
• Publication Date: 2017-12-22T21:38:33Z
• Authors: Paul E. Wischmeyer; Madelyn Kahana; Rachel Wolfson; Hongyu Ren; Mark M. Musch; Eugene B. Chang
• Keywords: Concomitant

Enhanced expression of heat shock protein (HSP) has been shown to be protective against laboratory models septic shock. Induction HSPs improve outcome in human disease not exploited because induction agents are themselves toxic and clinically relevant. In this study, we demonstrate that a single dose intravenous glutamine causes rapid significant increase HSP25 HSP72 multiple organs the unstressed Sprague-Dawley rat. With utilization fluid-resuscitated rat model endotoxemia, mortality was dramatically reduced by administration concomitant with endotoxin injury. Endotoxin-treated animals given exhibited dramatic increases tissue HSP marked reduction end-organ damage. These data suggest may protect attenuate injury endotoxemic via enhanced expression. Furthermore, confers protection when administered at initiation sepsis, rather than as pretreatment. Thus appears viable enhancer prove beneficial therapy sepsis sepsis-induced organ