Chronic administration of therapeutic levels of clenbuterol acts as a repartitioning agent

• DOI: 10.1152/jappl.2001.91.5.2064
• Publication Date: 2017-12-22T21:42:38Z
• Authors: Charles F. Kearns; Kenneth H. McKeever; Karyn Malinowski; Maggie B. Struck; Takashi Abe
• Keywords: Clenbuterol; Fat free mass

The purpose of this study was to examine the effect therapeutic levels clenbuterol, with and without exercise training, on body composition. Twenty-three unfit Standardbred mares were divided into four experimental groups: clenbuterol (2.4 μg/kg wt twice daily) plus (ClenEx; 20 min at 50% maximal oxygen consumption 3days/wk; n = 6), only (Clen; (Ex; 5), control (Con; 6). Rump fat thickness measured 2-wk intervals by using B-mode ultrasound, percent (%fat) calculated previously published methods. For Ex, decreased ( P < 0.05) week 4 (−9.3%), %fat 6 (−6.9%), fat-free mass (FFM) increased 8 (+3.2%). On other hand, Clen had significant changes in (−15.4%), (−14.7%), FFM (+4.3%) 2. ClenEx decreases (−17.6%) (−19.5%) 2, which similar Clen; however, group a different response, significantly (+4.4%) 6. Con showed no > any variable time. These results suggest that training have additive effects respect but antagonistic terms FFM. Furthermore, chronic administration causes repartitioning horse, even when administered doses.