Satellite cell depletion does not affect diaphragm adaptations to hypoxia

• DOI: 10.1152/japplphysiol.00083.2022
• Publication Date: 2022-07-21T12:53:17Z
• Authors: Nicholas T. Thomas; Amy L. Confides; Christopher S. Fry; Esther E. Dupont-...
• Keywords: Hypoxia; Diaphragm muscle; Diaphragm (acoustics)

Satellite cells show consistent fusion into diaphragm muscle fibers throughout life, suggesting a critical role in maintaining homeostasis. Here, we report identical adaptations to hypoxia with and without satellite adult aged mice. In addition, propose that the higher number of Pax3-positive cell-depleted acts as compensatory mechanism.