Impact of ventilation strategies during chest compression. An experimental study with clinical observations

• DOI: 10.1152/japplphysiol.00632.2015
• Publication Date: 2015-12-02T22:02:52Z
• Authors: Ricardo L. Cordioli; Aissam Lyazidi; Nathalie Rey; Jean-Max Granier; Dominique Savary; Laurent Brochard; Jean-Christophe M...
• Keywords: Positive End-Expiratory Pressure; Thorax (insect anatomy); Positive pressure; Mallinckrodt

The optimal ventilation strategy during cardiopulmonary resuscitation (CPR) is unknown. Chest compression (CC) generates circulation, while decompression, thoracic recoil negative pressure and venous return. Continuous flow insufflation of oxygen (CFI) allows noninterrupted CC positive airway (Paw). main objective this study was to assess the effects Paw compared with current recommended on intrathoracic (P IT ) variations, ventilation, lung volume. In a mechanical model, allowing thorax below an equilibrium volume mimicking functional residual capacity (FRC), alone or manual bag were two levels CFI. Lung change FRC at end decompression P , as well estimated alveolar measured bench study. Recordings obtained in five cardiac arrest patients confirm findings. continuously FRC, consequence remained all situations, including Paw. Compared alone, CFI limited fall resulted larger variations. Positive significantly augmented induced by CC. confirmed major loss CPR, even associated limits volume, enhances CC-induced maintains more ventilation.