Effect of racial background on motor cortical function as measured by threshold tracking transcranial magnetic stimulation

• DOI: 10.1152/jn.00083.2021
• Publication Date: 2021-08-18T16:33:31Z
• Authors: Yo-Ichi Suzuki; Yan Ma; Kazumoto Shibuya; Sonoko Misawa; Tomoki Suichi; Atsuko Tsuneyama; Keigo Nakamura; José Manuel Matamala; Thanuja Dharmadasa; Steve Vucic; Dongsheng Fan; Matthew C. Kiernan; Satoshi Kuwabara
• Keywords: Silent period; Evoked potential

A previous study using traditional paired-pulse TMS methods (amplitude-tracking) has reported differences in resting motor threshold (RMT) and short-interval intracortical inhibition (SICI) between healthy subjects of Caucasian Han Chinese backgrounds, probably due to the skull shape. The amplitude-tracking method delivers stimuli with constant intensity causes substantial variabilities motor-evoked potential amplitudes. To overcome this variability, tracking transcranial magnetic stimulation (TT-TMS) been developed. present aimed investigate whether racial cortical function exist, TT-TMS. total 83 volunteers (30 Caucasians, 25 Chinese, 28 Japanese) were included series. In TT-TMS nerve conduction studies, electrodes placed on dominant limb, measures recorded from abductor pollicis brevis muscle. Stimulations delivered a circular coil, directly above primary cortex. There no significant at all SICI intervals races. Similarly, there other excitability including mean RMT, facilitation, silent period. Contrary TMS, thereby is minimally influenced by when measured Recent studies have disclosed that differentiates amyotrophic lateral sclerosis (ALS) ALS mimic disorders, high sensitivity specificity, Caucasians. This suggested can be applied for diagnosis Asian patients, as well Caucasians.NEW & NOTEWORTHY Threshold was Japanese. No found indexes among differentiate