Adaptations to maternal WSD-feeding and metformin use on fetal islets from non-human primate offspring

• DOI: 10.1152/physiol.2024.39.s1.2498
• Publication Date: 2024-05-21T14:57:50Z
• Authors: Darian Thomas Car...; Jennifer Fuhr; Rene Lindsley; Melissa Kirigiti; Tyler Dean; Carrie McCurdy; Stephanie Wesolowski
• Keywords: Non human primate

Given the current increased prevalence of diabetes in pregnancy, potential relative risks and benefits oral glycemic agents on developing offspring should be evaluated considered. Metformin (Met) is a common agent prescribed pregnancy that not metabolized, but renally excreted actively transported across placenta. Thus, fetus exposed to near equivalent maternal adult doses with subsequent risk adverse consequences. Using non-human primate model overnutrition, our group previously demonstrated developmental exposure Western-style diet (WSD) results an inappropriate increase glucose-stimulated insulin secretion changes expression several ion channels involved islets from juvenile offspring. overnutrition excess energy supply while Met inhibits mitochondrial respiration, we hypothesize WSD-feeding will result maladaptive beta-cell function fetus. Static assays chow (CD) WSD +/- Met-exposed show no differences secretion. Nevertheless, mWSD+Met-exposed showed lower oxygen consumption extracellular acidification rate mWSD+placebo fetal islets, suggesting influences programming adaptation islets. Therefore, predict metabolic response intrauterine differs depending diet. Elucidation mechanisms mediating adaptations during development may provide insight interventions avoid failure as they age. All nonhuman studies were supported part by Oregon National Primate Research Center grant P51 OD011092 Institutes Health/Offce Director. D.T.C. was Vanderbilt University Training Program Molecular Endocrinology (5T32 DK563-30) predoctoral fellowship NIH/NIDDK (1F31 DK135164).T.A.D., C.E.M., K.M.A., J.E.F., P.K., M.G. Grants R24 DK090964 R01 DK128187. This full abstract presented at American Physiology Summit 2024 meeting only available HTML format. There are additional versions or content for this abstract. peer review process.