Ameliorating immune-dependent inflammation and apoptosis by targeting TLR4/MYD88/NF-κB pathway by celastrol mitigates the diabetic reproductive dysfunction

• DOI: 10.1152/physiolgenomics.00072.2024
• Publication Date: 2024-11-08T00:26:18Z
• Authors: Heba Faheem; Rana Alawadhi; Eman H. Basha; Radwa Ismail; Hoda A. Ibrahim; Amira M. Elshamy; Shaimaa M. Motawea; Monira A. Seleem; Alaa Elkordy; Abdallah A. Homouda; Howayda E. Khaled; Reham A. Aboeida; Muhammad T. Abdel...; Fatma H. Rizk; Yasmeen M. El-Harty
• Keywords: 0301 basic medicine; 03 medical and health sciences

Celastrol inhibits the production of proinflammatory cytokines in the testicular tissue by specifically targeting the TLR4/MyD88/NF- κB signaling cascade pathways. This indicates that celastrol may serve as a promising new therapeutic target for treating diabetic reproductive dysfunction.