The Role of Specific Mitogen-Activated Protein Kinase Signaling Cascades in the Regulation of Steroidogenesis

• DOI: 10.1155/2011/821615
• Publication Date: 2011-01-05T19:52:16Z
• Authors: Pulak R. Manna; Douglas M. Stocco
• Keywords: ASK1; c-Raf; MAP2K7

Mitogen-activated protein kinases (MAPKs) comprise a family of serine/threonine that are activated by large variety extracellular stimuli and play integral roles in controlling many cellular processes, from the cell surface to nucleus. The MAPK includes four distinct cascades, is, signal-regulated kinase 1/2 (ERK1/2), p38 MAPK, c-Jun N-terminal or stress-activated kinase, ERK5. These MAPKs essentially operated through three-tiered consecutive phosphorylation events catalyzed MAPK. lie cascades. signaling pathways have been demonstrated be associated with regulating expression steroidogenic acute regulatory (StAR) steroidogenesis tissues. However, it has become clear regulation MAPK-dependent StAR steroid synthesis is complex process context dependent. This paper summarizes current level understanding concerning cascades different models.