The Rapid Initiation, Titration, and Transition from Intravenous to Oral Treprostinil in a Patient with Severe Pulmonary Arterial Hypertension

• DOI: 10.1155/2015/498981
• Publication Date: 2015-09-19T21:02:53Z
• Authors: James Benjamin Gl...; Justin Dolan; Pirouz Piran; Franck Farzad Rah...
• Keywords: Treprostinil; Contraindication; Persistent pulmonary hypertension; Phlebotomy; Prostanoid

In patients who require urgent initiation of pulmonary arterial hypertension medications due to disease progression, it is customary start intravenous prostacyclin therapy, typically during a hospital admission. If there are complicating factors or relative contraindications and subcutaneous prostanoids, oral treprostinil provides another pathway prostanoid but this usually requires prolonged titration. We describe the case thirty-six-year-old male with severe contraindication therapy congenital deafness risk not hearing pump alarms. Intravenous was initiated, titrated high dose, then rapidly transitioned treprostinil. A rapid initiation, titration, transition from can be safely performed under watchful supervision in order achieve higher more efficacious doses timely manner.