The Impacts ofSLC22A1rs594709 andSLC47A1rs2289669 Polymorphisms on Metformin Therapeutic Efficacy in Chinese Type 2 Diabetes Patients

• DOI: 10.1155/2016/4350712
• Publication Date: 2016-02-10T21:03:41Z
• Authors: Di Xiao; Yu Guo; Xi Li; Ji-Ye Yin; Wei Zheng; Xin-Wen Qiu; Ling Xiao; Rang-Ru Liu; Sai-Ying Wang; Wei-Jing Gong; Hong-Hao Zhou; Zhao-Qian Liu
• Keywords: 0301 basic medicine; 03 medical and health sciences; RC648-665; Diseases of the endocrine glands. Clinical endocrinology; Research Article; 3. Good health

Background. We aimed to investigate the distributive characteristics of SLC22A1 rs594709 and SLC47A1 rs2289669 polymorphisms their influence on metformin efficacy in Chinese T2DM patients. Methods. The distributions were determined 267 patients 182 healthy subjects. Subsequently, 53 newly diagnosed who received monotherapy recruited evaluate efficacy. Results. No significant difference was found between subjects allele frequencies genotype frequencies. After treatment, GG showed a higher increase FINS (p = 0.015) decrease HOMA-IS 0.001) QUICKI 0.002) than A carriers. had TChol 0.030) LDL-C 0.049) Among AA genotype, with FBG 0.015), PINS 0.041), HOMA-IR 0.014) G However, among carriers, 0.013) Conclusion. Our data suggest that may together