Influence of the Melissa officinalis Leaf Extract on Long‐Term Memory in Scopolamine Animal Model with Assessment of Mechanism of Action

• DOI: 10.1155/2016/9729818
• Publication Date: 2016-04-28T21:24:16Z
• Authors: Marcin Ozarowski; Przemyslaw L. Mik...; Anna Piasecka; Piotr Kachlicki; Radoslaw Kujawski; Anna Bogacz; Joanna Bartkowiak...; Michal Szulc; Ewa Kaminska; Malgorzata Kujawska; Jadwiga Jodynis-L...; Agnieszka Gryszcz...; Bogna Opala; Zdzislaw Lowicki; Agnieszka Seremak...; Boguslaw Czerny
• Keywords: Melissa Officinalis; Butyrylcholinesterase; Rosmarinic acid; Huperzine A

Melissa officinalis (MO, English: lemon balm, Lamiaceae), one of the oldest and still most popular aromatic medicinal plants, is used in phytomedicine for prevention treatment nervous disturbances. The aim our study was to assess effect subchronic (28-fold) administration a 50% ethanol extract MO leaves (200 mg/kg, p.o.) compared with rosmarinic acid (RA, 10 huperzine A (HU, 0.5 on behavioral cognitive responses scopolamine-induced rats. results were linked acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), beta-secretase (BACE-1) mRNA levels AChE BuChE activities hippocampus frontal cortex In study, HU, but not RA, showed an improvement long-term memory. line levels, since produced decrease level by 52% caused strong significant inhibition BACE1 transcription (64% cortex; hippocampus). However, only insignificant activity cortex. mechanisms action are probably more complicated, its role as modulator should be taken into consideration.