Hmox1Deficiency Sensitizes Mice to Peroxynitrite Formation and Diabetic Glomerular Microvascular Injuries

• DOI: 10.1155/2017/9603924
• Publication Date: 2017-11-22T18:31:49Z
• Authors: Olivia Lenoir; François Gaillard; Hélène Lazareth; Blaise Robin; Pierre-Louis Tharaux
• Keywords: HMOX1; Nitrotyrosine; Albuminuria

Objective. Indirect evidence suggests a role for heme oxygenase-1 (HO-1) in limiting diabetic vasculopathy. The goal of this study was to assess the HO-1 development microvascular lesions within glomeruli during diabetes mellitus using mouse model with specific alteration Hmox1 gene. Approach and Results. effects haploinsufficiency were studied as means assessing intrinsic contribution renal diabetes. Renal function histology analyzed 10 weeks after induction streptozotocin. Diabetic +/− mice showed higher levels albuminuria blood urea compared their wild-type littermates. More severe glomerular also observed mice. This associated increase expression oxidative stress marker, nitrotyrosine. Conclusions. Genetic partial deficiency is sufficient sensitize lesions. exerts antioxidant kidney mellitus. These have protective on endothelial injury.