Laryngopharyngeal Reflux Is a Potential Risk Factor for Juvenile-Onset Recurrent Respiratory Papillomatosis

• DOI: 10.1155/2019/1463896
• Publication Date: 2019-02-10T23:30:46Z
• Authors: Martin Formánek; Pavel Komínek; Debora Jančatová; Lucia Staníková; Radoslava Tomanová; Jana Vaculová; Milan Urík; Ivo Šlapák; Karol Zeleník
• Keywords: Recurrent Respiratory Papillomatosis; Laryngopharyngeal Reflux; Papillomatosis

Human papillomavirus (HPV) causes juvenile-onset recurrent respiratory papillomatosis (JORRP). Although HPV is common in children, the prevalence of JORRP low. It likely that other factors contribute to pathogenesis JORRP, during either activation or reactivation a latent infection. There evidence laryngopharyngeal reflux (LPR) might be such risk factor for adult-onset papillomatosis. This study investigated if LPR also JORRP.Children with larynx required microlaryngoscopy at tertiary referral hospital were included this prospective case-series from November 2015 2017. Using immunohistochemistry, infection and pepsin associated diagnosed laryngeal biopsies.Eleven children (aged 4-14 years) analyzed. No patient had history immunodeficiency tobacco smoke exposure. All patients underwent least three previous surgeries due been vaccinated against past. Five treated using antivirotics immunomodulators. The only known maternal was mothers primiparous. 11 samples infected (type 6 11). Pathologic 5/11 (45.5%).LPR may contributing its development by activating reactivating Results are accordance those our adults.