The Effect of Adipose-Derived Stem Cells on Wound Healing: Comparison of Methods of Application

• DOI: 10.1155/2019/2745640
• Publication Date: 2019-09-17T23:30:23Z
• Authors: Hyeonwoo Kim; Mi Ri Hyun; Sang Wha Kim
• Keywords: 0301 basic medicine; 03 medical and health sciences; Internal medicine; RC31-1245; Research Article; 3. Good health

Impaired wound healing is a significant medical problem. Recently, cell-based therapy focused on stem cells has been developed to overcome the challenges of defective healing. In this study, we aimed evaluate effectiveness adipose-derived (ASCs) in promoting healing, using different techniques for administering them. Dorsal full-thickness skin defects (1 × 1 cm) were created three groups mice that received intravenous ASCs by injection, intramuscular and topical application, respectively. Three control saline same ways. Wound was assessed clinically, wounds examined histologically, GFP-labelled detected with an IVIS imaging system. The results revealed accelerated independent their mode administration. Histological examination showed reepithelialization, analysis indicated many present area disappeared after