Data from Type 1 Insulin-like Growth Factor Receptor Translocates to the Nucleus of Human Tumor Cells

• DOI: 10.1158/0008-5472.c.6500177.v1
• Publication Date: 2023-03-31T01:04:31Z
• Authors: Tamara Aleksic; Meenali M. Chitnis; Olga V. Perestenko; Shan Gao; Peter H. Thomas; Gareth D. Turner; Andrew S. Protheroe; Mark Howarth; Valentine M. Maca...
• Keywords: Nuclear export signal

<div>Abstract<p>The type 1 insulin-like growth factor receptor (IGF-1R) is a transmembrane glycoprotein composed of two extracellular α subunits and β with tyrosine kinase activity. The IGF-1R frequently upregulated in cancers signals from the cell surface to promote proliferation survival. Recent attention has focused on as target for cancer treatment. Here, we report that nuclei human tumor cells contain IGF-1R, detectable using multiple antibodies α- β-subunit domains. Cell-surface translocates nucleus following clathrin-mediated endocytosis, regulated by IGF levels. unusual among receptors undergo nuclear import, both traffic nucleus. Nuclear phosphorylated response ligand undergoes IGF-induced interaction chromatin, suggesting direct engagement transcriptional regulation. dependence these phenomena indicates requirement kinase, indeed, import chromatin binding can be blocked novel inhibitor. primary renal cells, formalin-fixed tumors, preinvasive lesions breast, nonmalignant tissues characterized high rate. In clear cancer, associated adverse prognosis. Our findings suggest biological significance, may contribute directly function, influence efficacy inhibitory drugs. Cancer Res; 70(16); 6412–9. ©2010 AACR.</p></div>