Data from Wnt/Snail Signaling Regulates Cytochrome <i>c</i> Oxidase and Glucose Metabolism

• DOI: 10.1158/0008-5472.c.6502962.v1
• Publication Date: 2023-03-31T23:07:36Z
• Authors: Su Yeon Lee; Hyun Min Jeon; Min Kyung Ju; Cho Hee Kim; Gyesoon Yoon; Song Iy Han; Hye Gyeong Park; Ho Sung Kang

&lt;div&gt;Abstract&lt;p&gt;Wnt signaling plays a critical role in embryonic development, and its deregulation is closely linked to the occurrence of number malignant tumors, including breast colon cancer. The pathway also induces Snail-dependent epithelial-to-mesenchymal transition (EMT), which responsible for tumor invasion metastasis. In this study, we show that Wnt suppresses mitochondrial respiration cytochrome C oxidase (COX) activity by inhibiting expression 3 COX subunits, namely, COXVIc, COXVIIa, COXVIIc. We found induced glycolytic switch via increased glucose consumption lactate production, with induction pyruvate carboxylase (PC), key enzyme anaplerosis. addition, Wnt-induced repression switching occurred through canonical β-catenin/T-cell factor 4/Snail pathway. Short hairpin RNA–mediated knockdown E-cadherin, regulator EMT, repressed Snail activation, indicating EMT may contribute Wnt/Snail regulation metabolism. Together, our findings provide new function (via gene expression) metabolism PC growth progression. &lt;i&gt;Cancer Res; 72(14); 3607–17. ©2012 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;