Data from Peroxiredoxin-2 Represses Melanoma Metastasis by Increasing E-Cadherin/β-Catenin Complexes in Adherens Junctions

• DOI: 10.1158/0008-5472.c.6504536.v1
• Publication Date: 2024-03-12T19:05:49Z
• Authors: Doo Jae Lee; Dong Hoon Kang; Mina Choi; Yang Ji Choi; Joo Young Lee; Joo Hyun Park; Yoon Jung Park; Kyung Wha Lee; Sang Won Kang
• Keywords: Adherens junction

<div>Abstract<p>In melanoma, transition to the vertical growth phase is critical step in conversion a deadly malignant disease. Here, we offer first evidence that an antioxidant enzyme has key role this transition. We found peroxiredoxin-2 (Prx2) inversely correlated with metastatic capacity of human melanoma cells. Silencing Prx2 expression stimulated proliferation and migration, whereas ectopic produced opposite effect. Mechanistic investigations indicated negatively regulated Src/ERK activation status, which turn fortified adherens junctions function by increasing E-cadherin phospho-Y654–dependent retention β-catenin plasma membrane. In murine cells, silencing enhanced lung metastasis <i>in vivo</i>. Interestingly, natural compound gliotoxin, known exert Prx-like activity, inhibited migration as well Prx2-deficient Overall, our findings reveal regulator invasion also suggest pharmacologic strategy effectively decrease forms <i>Cancer Res; 73(15); 4744–57. ©2013 AACR</i>.</p></div>