Data from Enriching the Housing Environment for Mice Enhances Their NK Cell Antitumor Immunity via Sympathetic Nerve–Dependent Regulation of NKG2D and CCR5

• DOI: 10.1158/0008-5472.c.6509606.v1
• Publication Date: 2023-03-31T22:08:38Z
• Authors: Yanfang Song; Yu Gan; Qing Wang; Zihong Meng; Guohua Li; Yuling Shen; Yufeng Wu; Peiying Li; Ming Yao; Jianren Gu; Hong Tu
• Keywords: NKG2D

<div>Abstract<p>Mice housed in an enriched environment display a tumor-resistant phenotype due to eustress stimulation. However, the mechanisms underlying environment–induced protection against cancers remain largely unexplained. In this study, we observed significant antitumor effect induced by murine pancreatic cancer and lung models. This remained intact T/B lymphocyte-deficient Rag1<sup>−/−</sup> mice, but was nearly eliminated natural killer (NK) cell–deficient Beige mice or antibody-mediated NK-cell–depleted suggesting predominant role of NK cells tumor inhibition. Exposure enhanced NK-cell activity tumors promoted tumoral infiltration cells. Enriched increased expression levels CCR5 NKG2D (KLRK1) cells; blocking their function effectively blunted enhancement cytotoxic Moreover, blockade β-adrenergic signaling chemical sympathectomy abolished effects on attenuated environment. Taken together, our results provide new insight into mechanism which exerts beneficial cancer. <i>Cancer Res; 77(7); 1611–22. ©2017 AACR</i>.</p></div>