Data from GSK3β-Mediated Expression of CUG-Translated WT1 Is Critical for Tumor Progression

• DOI: 10.1158/0008-5472.c.6512422.v1
• Publication Date: 2023-03-31T06:18:46Z
• Authors: Hisae Yoshitomi; Kun Y. Lee; Ke Yao; Seung Ho Shin; Tianshun Zhang; Qiushi Wang; Souren Paul; Eunmiri Roh; Joohyun Ryu; Hanyong Chen; Faisal Aziz; Abhijit Chakraborty; Ann M. Bode; Zigang Dong
• Keywords: Tumor progression

<div>Abstract<p>The <i>Wilms' tumor 1</i> (<i>WT1</i>) gene is well known as a chameleon gene. It plays role suppressor in Wilms' but also acts an oncogene other cancers. Previously, our group reported that canonical AUG starting site for the WT1 protein (augWT1) suppressor, whereas CUG (cugWT1) functions oncogene. In this study, we report oncogenic of cugWT1 AOM/DSS-induced colon cancer mouse model and urethane-induced lung mice lacking cugWT1. Development chemically-induced tumors was significantly depressed cugWT1-deficient mice. Moreover, glycogen synthase kinase 3β promoted phosphorylation at S64, resulting ubiquitination degradation associated with F-box<sup>−/−</sup> WD repeat-containing 8. Overall, findings suggest inhibition expression provides potential candidate target therapy.</p>Significance:<p>These demonstrate CUG-translated <i>in vivo</i>, GSK3β-mediated induces its concert FBXW8.</p></div>