Data from Time-Dependent Effects of Oral Contraceptive Use on Breast, Ovarian, and Endometrial Cancers

• DOI: 10.1158/0008-5472.c.6512680.v1
• Publication Date: 2023-03-31T21:32:57Z
• Authors: Torgny Karlsson; Therese Johansson; Julia Höglund; Weronica E. Ek; Åsa Johansson

<div>Abstract<p>Oral contraceptive use has been suggested to influence the risk of breast, ovarian, and endometrial cancer. The purpose this study is clarify time-dependent effects between long-term oral cancer risk. We performed an observational in 256,661 women from UK Biobank, born 1939 1970. Information on diagnoses were collected self-reported data national registers until March 2019. Cumulative over timespan study, as measured by OR, instantaneous risk, HR, assessed using Logistic Cox regression analyses, respectively. odds lower among ever users, compared with never for ovarian [OR = 0.72; 95% confidence interval (CI), 0.65–0.81] (OR 0.68; CI, 0.62–0.75), association that was stronger longer (<i>P</i> < 0.001). Increased seen breast when limiting follow-up 55 years age 1.10; 1.03–1.17), but not full timespan. only found a higher HR former users immediately (≤2 years) after discontinued (HR 1.55; 1.06–2.28), whereas protective remained significant up 35 last contraceptives. Given body evidence presented our we argue contraceptives can dramatically reduce women's cancer, their effect lifetime limited.</p>Significance:<p>These results enable physicians make more informed decisions considering use, thus constituting important step toward personalized medicine.</p></div>