Data from Novel Oncogenic Transcription Factor Cooperation in RB-Deficient Cancer

• DOI: 10.1158/0008-5472.c.6567234.v1
• Publication Date: 2023-04-06T17:01:23Z
• Authors: Amy C. Mandigo; Ayesha A. Shafi; Jennifer J. McCann; Wei Yuan; Talya S. Laufer; Denisa Bogdan; Lewis Gallagher; Emanuela Dylgjeri; Galina Semenova; Irina A. Vasilevs...; Matthew J. Schiewer; Chris M. McNair; Johann S. de Bono; Karen E. Knudsen
• Keywords: E2F1; E2F; Retinoblastoma

<div>Abstract<p>The retinoblastoma tumor suppressor (RB) is a critical regulator of E2F-dependent transcription, controlling multitude protumorigenic networks including but not limited to cell-cycle control. Here, genome-wide assessment E2F1 function after RB loss in isogenic models prostate cancer revealed unexpected repositioning and cooperation with oncogenic transcription factors, the major driver disease progression, androgen receptor (AR). Further investigation that observed AR/E2F1 elicited novel transcriptional promote phenotypes, especially as related evasion cell death. These observations were reflected human disease, indicating clinical relevance cooperome cancer. Together, these studies reveal new mechanisms by which induces progression highlight importance understanding targets function.</p>Significance:<p>This study identifies drives between AR coregulators linked advanced disease.</p></div>