Circulating Levels of Inflammatory Cytokines and Risk of Colorectal Adenomas

• DOI: 10.1158/0008-5472.can-07-2924
• Publication Date: 2008-01-03T02:02:33Z
• Authors: Sangmi Kim; Temitope O. Keku; Christopher Martin; Joseph Galanko; John T. Woosley; Jane C. Schroeder; Jessie A. Satia; Susan Halabi; Robert S. Sandler
• Keywords: Colorectal adenoma; Proinflammatory cytokine

Abstract The association between obesity and colorectal neoplasia may be mediated by inflammation. Circulating levels of C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) are elevated in the obese. Adipose tissue can produce release inflammatory cytokines that potentially procarcinogenic. We examined circulating CRP, IL-6, TNF-α relation to risk factors prevalence adenomas. Plasma were quantified 873 participants (242 adenoma cases 631 controls) a colonoscopy-based cross-sectional study conducted 1998 2002. Multivariable logistic regression was used estimate associations known for Several associated with higher cytokines, including older age, current smoking, increasing adiposity. adenomas concentrations IL-6 and, lesser degree, CRP. For adjusted odds ratios (OR) 1.79 [95% confidence interval (CI), 1.19–2.69] second highest plasma level 1.85 (95% CI, 1.24–2.75) compared reference level. A similar found TNF-α, ORs 1.56 1.03–2.36) 1.66 1.10–2.52), respectively. Our findings indicate systemic inflammation might involved early development neoplasia. [Cancer Res 2008;68(1):323–8]