Supplementary Figure S4 from Platinum-Based Chemotherapy Attenuates the Effector Response of CD8 T Cells to Concomitant PD-1 Blockade

• DOI: 10.1158/1078-0432.25728647.v1
• Publication Date: 2024-05-01T13:13:14Z
• Authors: Annapaola Mariniello; Tahseen H. Nasti; Daniel Y. Chang; Masao Hashimoto; Sakshi Malik; Daniel T. McManus; Judong Lee; Donald J. McGuire; Maria A. Cardenas; Pablo Umana; Valeria Nicolini; Rustom Antia; Ananya Saha; Zachary Buchwald; Hayden Kissick; Ehsan Ghorani; Silvia Novello; Dario Sangiolo; Giorgio V. Scagli...; Suresh S. Ramalingam; Rafi Ahmed
• Keywords: Concomitant

<p>A) Number of total lymphocytes and CD8+ T cells in the spleen mice treated with either concomitant or sequential combination CT aPD-L1. (B) Representative FACS plots showing frequency stem-like (PD-1+TCF-1+TIM-3-), effector transitory (PD-1+CX3CR1+TIM-3+) terminally differentiated (PD-1+CD101+TIM-3+) Gp33+ CD8 across treatment groups, quantified numbers shown (C). Data are pooled from 2 independent experiments 4-6 per group. For statistical analysis T-test was used, were Log10 transformed. Bars represent mean SEM. * p<0.05; ** p<0.01; **** p<0.0001.</p>