Expression and Growth Dependency of the Insulin-Like Growth Factor I Receptor in Craniopharyngioma Cells: A Novel Therapeutic Approach

• DOI: 10.1158/1078-0432.ccr-05-0129
• Publication Date: 2005-09-21T23:49:26Z
• Authors: Elfar Ulfarsson; Alexandra Karström; Shucheng Yin; Ada Girnita; Daiana Vasilcanu; Marja Thoren; Gunnar Kratz; Jan Hillman; Magnus Axelson; Olle Larsson; Leonard Girnita
• Keywords: Craniopharyngioma; Growth inhibition; Receptor expression

Craniopharyngioma is a rare benign intracranial epithelial tumor that, however, often recurs and sometimes kills the affected patients, one-third of which are children. In many cases, patients acquire growth hormone deficiency postoperatively need substitution. Generally, promotes local release insulin-like factor I (IGF-I), in turn activates IGF-I receptor (IGF-IR) if present. Together, these circumstances raise question whether IGF-IR may be involved craniopharyngioma growth. To address this issue, we analyzed phenotypically well-characterized primary low-passage cell lines from nine different for expression dependency. Two showed no/very low was independent on IGF-I, whereas five exhibited strong clearly contingent IGF-I. The two remaining had Upon treatment with an inhibitor, cells high responded promptly decreased Akt phosphorylation followed by arrest. These responses were not seen expression. Growth only slightly inhibition. Taken together, our data suggest that subset craniopharyngiomas points to possibility involvement inhibitors as modality obtain complete tumor-free conditions before