Data from Chemopreventive Effects of Korean Angelica versus Its Major Pyranocoumarins on Two Lineages of Transgenic Adenocarcinoma of Mouse Prostate Carcinogenesis

• DOI: 10.1158/1940-6207.c.6545025
• Publication Date: 2024-03-12T20:31:17Z
• Authors: Su-Ni Tang; Jinhui Zhang; Wei Wu; Peixin Jiang; Manohar Puppala; Yong Zhang; Chengguo Xing; Sung-Hoon Kim; Cheng Jiang; Junxuan Lü

<div>Abstract<p>We showed previously that daily gavage of <i>Angelica gigas</i> Nakai (AGN) root ethanolic extract starting 8 weeks age inhibited growth prostate epithelium and neuroendocrine carcinomas (NE-Ca) in the transgenic adenocarcinoma mouse (TRAMP) model. Because decursin (D) its isomer decursinol angelate (DA) are major pyranocoumarins AGN extract, we tested hypothesis D/DA represented active/prodrug compounds against TRAMP carcinogenesis. Three groups male C57BL/6 mice were treated with excipient vehicle, (5 mg per mouse), or equimolar (3 mouse) from to 16 28 age. Measurement plasma NE-Ca D, DA, their common metabolite indicated similar retention versus dosing. The dorsolateral (DLP) AGN- D/DA-treated was by 66% 61% at 67% 72% weeks, respectively. Survival bearing improved AGN, but not D/DA. Nevertheless, had lower burden. Immunohistochemical mRNA analyses DLP exerted inhibition epithelial lesion progression key cell-cycle genes. Profiling a greater scope modulating angiogenesis, epithelial–mesenchymal transition, invasion–metastasis, inflammation genes than data therefore support as probable lesions, they cooperate non-pyranocoumarin fully express efficacy NE-Ca. <i>Cancer Prev Res; 8(9); 835–44. ©2015 AACR</i>.</p></div>