Data from Implementation of HPV-based Cervical Cancer Screening Combined with Self-sampling Using a Midwifery Network Across Rural Greece: The GRECOSELF Study

• DOI: 10.1158/1940-6207.c.6547463.v1
• Publication Date: 2023-04-04T20:07:08Z
• Authors: Theodoros Agorastos; Kimon Chatzistama...; Athena Tsertanidou; Evangelia Mouchta...; Konstantinos Pase...; Anastasia Kitsou; Theodoros Moysiadis; Viktoria Moschaki; Alkmini Skenderi; Evangelia Katsiki; Stamatia Aggelidou; Ioannis Venizelos; Maria Ntoula; Alexandros Daponte; Polyxeni Vanakara; Antonios Garas; Theodoros Stefos; Thomas Vrekoussis; Vasilis Lymberis; Emmanuel N. Konto...; Antonis Makrigian...; George Manidakis; Efthimios Deligeo...; Theodoros Panoska...; George O. Decavalas; George Michail; Ioannis Kalogiann...; George Koukoulis; Paraskevi Zempili; Despina Halatsi; Theoni Truva; Vaia Piha; Georgia Agelena; Athanasia Chronop...; Violetta Vaitsi; Ekaterini Chatzaki; Minas Paschopoulos; George Adonakis; Andreas M. Kaufmann; Anastasia Hadzidi...; Kostas Stamatopoulos

<div>Abstract<p>Self-sampling for human papillomavirus (HPV) testing is an alternative to physician sampling particularly cervical cancer screening nonattenders. The GRECOSELF study a nationwide observational cross-sectional aiming suggest way implement HPV-DNA in conjunction with self-sampling Greece, utilizing midwifery network. Women residing remote areas of Greece were approached by midwives, network, and provided self-collection kit (dry swab) cervicovaginal asked answer questionnaire about their history. Each sample was tested high-risk (hr) HPV the Cobas test. HrHPV-Positive women referred undergo colposcopy and, if needed, treatment according colposcopy/biopsy results. Between May 2016 November 2018, 13,111 recruited. Of these, 12,787 gave valid answers had results; hrHPV prevalence 8.3%; high-grade cervical/vaginal disease or 0.6%. HrHPV positivity rate decreased age from 20.7% aged 25–29 years 5.1% 50–60 years. Positive predictive value HPV16/18 genotyping ranged 5.0% 11.6% 11.8% 27.0%, respectively, different groups. Compliance referral 68.6% (for 25–29) 76.3% 40–49). For detection DNA test, on self-collected samples using dry cotton swabs, which are visiting promising method secondary prevention.</p></div>