Supplementary Figure S6 from Discovery of BBO-8520, a First-In-Class Direct and Covalent Dual Inhibitor of GTP-Bound (ON) and GDP-Bound (OFF) KRAS^G12C

• DOI: 10.1158/2159-8290.28522807
• Publication Date: 2025-03-03T08:20:30Z
• Authors: Anna E. Maciag; James P. Stice; Bin Wang; Alok K. Sharma; Albert H. Chan; Ken Lin; Devansh Singh; Marcin Dyba; Yue Yang; Saman Setoodeh; Brian P. Smith; Jin Hyun Ju; Stevan Jeknic; Dana Rabara; Zuhui Zhang; Erik K. Larsen; Dominic Esposito; John-Paul Denson; Michela Ranieri; Mary Meynardie; Sadaf Mehdizadeh; Patrick A. Alexander; Maria Abreu Blanco; David M. Turner; Rui Xu; Felice C. Lightstone; Kwok-Kin Wong; Andrew G. Stephen; Keshi Wang; Dhirendra K. Sima...; Kerstin W. Sinkev...; Dwight V. Nissley; Eli Wallace; Frank McCormick; Pedro J. Beltran

<p>Supplementary Figure S6 shows that BBO-8520 shows anti-tumor activity in NCI-H358 CDX sotorasib-resistant tumors</p>