Data from Large-Scale Evaluation of Common Variation in Regulatory T Cell–Related Genes and Ovarian Cancer Outcome

• DOI: 10.1158/2326-6066.c.6548789
• Publication Date: 2024-03-12T19:50:32Z
• Authors: Bridget Charbonneau; Kirsten B. Moysich; Kimberly R. Kalli; Ann L. Oberg; Robert A. Vierkant; Zachary C. Fogarty; Matthew S. Block; Matthew J. Maurer; Krista M. Goergen; Brooke L. Fridley; Julie M. Cunningham; David N. Rider; Claudia Preston; Lynn C. Hartmann; Kate Lawrenson; Chen Wang; Jonathan Tyrer; Honglin Song; Anna deFazio; Sharon E. Johnatty; Jennifer A. Doherty; Catherine M. Phelan; Thomas A. Sellers; Starr M. Ramirez; Allison F. Vitonis; Kathryn L. Terry; David Van Den Berg; Malcolm C. Pike; Anna H. Wu; Andrew Berchuck; Aleksandra Gentry...; Susan J. Ramus; Brenda Diergaarde; Howard Shen; Allan Jensen; Janusz Menkiszak; Cezary Cybulski; Jan Lubiński; Argyrios Ziogas; Joseph H. Rothstein; Valerie McGuire; Weiva Sieh; Jenny Lester; Christine Walsh; Ignace Vergote; Sandrina Lambrechts; Evelyn Despierre; Montserrat Garcia...; Hannah Yang; Louise A. Brinton; Beata Spiewankiewicz; Iwona K. Rzepecka; Agnieszka Dansonk...; Petra Seibold; Anja Rudolph; Lisa E. Paddock; Irene Orlow; Lene Lundvall; Sara H. Olson; Claus K. Hogdall; Ira Schwaab; Andreas du Bois; Philipp Harter; James M. Flanagan; Robert Brown; James Paul; Arif B. Ekici; Matthias W. Beckmann; Alexander Hein; Diana Eccles; Galina Lurie; Laura E. Hays; Yukie T. Bean; Tanja Pejovic; Marc T. Goodman; Ian Campbell; Peter A. Fasching; Gottfried Konecny; Stanley B. Kaye; Florian Heitz; Estrid Hogdall; Elisa V. Bandera; Jenny Chang-Claude; Jolanta Kupryjanczyk; Nicolas Wentzensen; Diether Lambrechts; Beth Y. Karlan; Alice S. Whittemore; Hoda Anton Culver; Jacek Gronwald; Douglas A. Levine; Susanne K. Kjaer; Usha Menon; Joellen M. Schild...; Celeste Leigh Pearce; Daniel W. Cramer; Mary Anne Rossing; Georgia Chenevix-...; Paul D.P. Pharoah; Simon A. Gayther; Roberta B. Ness; Kunle Odunsi; Lara E. Sucheston; Keith L. Knutson; Ellen L. Goode
• Keywords: Variation (astronomy)

<div>Abstract<p>The presence of regulatory T cells (Treg) in solid tumors is known to play a role patient survival ovarian cancer and other malignancies. We assessed inherited genetic variations via 749 tag single-nucleotide polymorphisms (SNP) 25 Treg-associated genes (<i>CD28</i>, <i>CTLA4</i>, <i>FOXP3</i>, <i>IDO1</i>, <i>IL10</i>, <i>IL10RA</i>, <i>IL15</i>, <i>1L17RA</i>, <i>IL23A</i>, <i>IL23R</i>, <i>IL2RA</i>, <i>IL6</i>, <i>IL6R</i>, <i>IL8</i>, <i>LGALS1</i>, <i>LGALS9</i>, <i>MAP3K8</i>, <i>STAT5A</i>, <i>STAT5B</i>, <i>TGFB1</i>, <i>TGFB2</i>, <i>TGFB3</i>, <i>TGFBR1</i>, <i>TGRBR2</i>, <i>TGFBR3</i>) relation survival. analyzed genotype overall 10,084 women with invasive epithelial cancer, including 5,248 high-grade serous, 1,452 endometrioid, 795 clear cell, 661 mucinous carcinoma cases European descent across 28 studies from the Ovarian Cancer Association Consortium (OCAC). The strongest associations were found for endometrioid <i>IL2RA</i> SNPs rs11256497 [HR, 1.42; 95% confidence interval (CI), 1.22–1.64; <i>P</i> = 5.7 × 10<sup>−6</sup>], rs791587 (HR, 1.36; CI, 1.17–1.57; 6.2 10<sup>−5</sup>), rs2476491 1.40; 1.19–1.64; 5.6 rs10795763 1.35; 7.9 cell <i>CTLA4</i> SNP rs231775 0.67; 0.54–0.82; 9.3 10<sup>−5</sup>) after adjustment age, study site, population stratification, stage, grade, oral contraceptive use. allele associated improved our also results an amino acid change CTLA4 previously has been reported be autoimmune conditions. Thus, we evidence that related Tregs seem survival, particularly patients cancer. <i>Cancer Immunol Res; 2(4); 332–40. ©2014 AACR</i>.</p></div>