Data from <i>Lnc-C/EBPβ</i> Negatively Regulates the Suppressive Function of Myeloid-Derived Suppressor Cells

• DOI: 10.1158/2326-6066.c.6549191
• Publication Date: 2024-03-12T19:47:35Z
• Authors: Yunhuan Gao; Wei Sun; Wencong Shang; Yuanyuan Li; Dan Zhang; Tianze Wang; Xipeng Zhang; Shiwu Zhang; Yuan Zhang; Rongcun Yang

&lt;div&gt;Abstract&lt;p&gt;Myeloid-derived suppressor cells (MDSC) are regulators of immune responses in cancer. The differentiation and function these MDSCs may be regulated through multiple factors, such as microRNAs. However, the effect long noncoding RNAs (lncRNA) on is poorly understood. We identified a RNA named &lt;i&gt;lnc-C/EBPβ&lt;/i&gt; MDSCs, which control suppressive functions MDSCs. &lt;i&gt;Lnc-C/EBPβ&lt;/i&gt; could induced &lt;i&gt;in vitro&lt;/i&gt; vivo&lt;/i&gt; tumor inflammatory environments. It set target transcripts, Arg-1, NOS2, NOX2, COX2, to immune-suppressive This lncRNA was also able bind C/EBPβ isoform LIP inhibit activation C/EBPβ. found that conserved homologue has similar murine &lt;i&gt;lnc-C/EBPβ&lt;/i&gt;. These findings suggest negative feedback role for controlling immunosuppressive MDSC environment. &lt;i&gt;Cancer Immunol Res; 6(11); 1352–63. ©2018 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;