Data from Self-Maintaining CD103⁺ Cancer-Specific T Cells Are Highly Energetic with Rapid Cytotoxic and Effector Responses

• DOI: 10.1158/2326-6066.c.6550399.v1
• Publication Date: 2023-04-04T19:39:18Z
• Authors: Megat Abd Hamid; Huw Colin-York; Nasullah Khalid-A...; Molly Browne; Lucia Cerundolo; Ji-Li Chen; Xuan Yao; Samara Rosendo-Ma...; Craig Waugh; David Maldonado-P...; Emma Bowes; Clare Verrill; Vincenzo Cerundolo; Christopher P. Co...; Marco Fritzsche; Yanchun Peng; Tao Dong
• Keywords: CTL*

<div>Abstract<p>Enrichment of CD103<sup>+</sup> tumor-infiltrating T lymphocytes (TIL) is associated with improved outcomes in patients. However, the characteristics human cytotoxic CD8<sup>+</sup> cells (CTL) and their role tumor control remain unclear. We investigated features antitumor mechanisms CTLs by assessing T-cell receptor (TCR)–matched CD103<sup>−</sup> cancer-specific CTL immunity <i>in vitro</i> its immunophenotype <i>ex vivo</i>. Interestingly, we found that differentiated expressed active form TGFβ1 to continually self-regulate CD103 expression, without relying on external TGFβ1-producing cells. The presence TCR antigen sensitivity, which enabled faster cancer recognition rapid cytotoxicity. These had elevated energetic potential migration capacity. they increased inhibitory coexpression apoptosis following prolonged exposure. Our data provide fundamental insights into properties matured CTLs, could have important implications for future designs tissue-localized immunotherapy strategies.</p></div>