Data from Gut Mycobiota Dysbiosis Is Associated with Melanoma and Response to Anti–PD-1 Therapy

• DOI: 10.1158/2326-6066.c.7160211
• Publication Date: 2024-04-02T07:25:38Z
• Authors: Natalia Szóstak; Luiza Handschuh; Anna Samelak-Czajka; Katarzyna Tomela; Bernadeta Pietrzak; Marcin Schmidt; Łukasz Galus; Jacek Mackiewicz; Andrzej Mackiewicz; Piotr Kozlowski; Anna Philips
• Keywords: Mycobiota; Dysbiosis

<div>Abstract<p>Recent research indicates that gut microbiota may be vital in the advancement of melanoma. In this study, we found melanoma patients exhibited a distinct mycobiota structure compared with healthy participants. <i>Candida albicans</i>, dubliniensis</i>, and <i>Neurospora crassa</i> were more abundant samples from melanoma, whereas <i>Saccharomyces cerevisiae</i> <i>Debaryomyces hansenii</i> less abundant. During anti–PD-1 treatment, relative amount <i>Malassezia restricta</i> <i>C. albicans</i> increased. A higher level paradoxus</i> was associated positive response to <i>Tetrapisispora blattae</i> lack clinical benefits. High levels <i>M. elevated serum lactate dehydrogenase, being overweight linked increased risk progression poorer treatment. Thus, study has revealed melanoma-associated mycobiome dysbiosis, characterized by altered fungal composition fungi species progression, identifying role for progression.</p></div>