Data from An IRF2-Expressing Oncolytic Virus Changes the Susceptibility of Tumor Cells to Antitumor T Cells and Promotes Tumor Clearance

• DOI: 10.1158/2326-6066.c.7267925.v1
• Publication Date: 2024-06-04T07:37:16Z
• Authors: Lulu Shao; Rashmi Srivastava; Greg M. Delgoffe; Stephen H. Thorne; Saumendra N. Sarkar

<div>Abstract<p>IFN regulatory factor 1 (IRF1) can promote antitumor immunity. However, we have shown previously that in the tumor cell, IRF1 growth, and IRF1-deficient cells exhibit severely restricted growth several syngeneic mouse models. Here, investigate potential of functionally modulating to reduce progression prolong survival. Using inducible expression, established it is possible regulate expression modulate B16-F10 tumors. Expression IRF2, which a functional antagonist IRF1, downregulated IFNγ-induced inhibitory ligands, upregulated MHC-related molecules, slowed extended We characterized domain(s) IRF2 needed for this activity, showing full-length was required its functions. Finally, using an oncolytic vaccinia virus as delivery platform, showed IRF2-expressing suppressed prolonged survival multiple These results suggest potency targeting immunotherapy.</p></div>