Blockade of Serotonin 2C Receptors with SB-242084 Moderates Reduced Locomotor Activity and Rearing by Cannabinoid 1 Receptor Antagonist AM-251

• DOI: 10.1159/000495939
• Publication Date: 2019-01-23T22:07:27Z
• Authors: Emese Bogáthy; Diana Kostyalik; Peter Petschner; Szilvia Vas; Gyorgy Bagdy
• Keywords: Cannabinoid receptor antagonist

The endocannabinoid and serotonin (5-HT) systems have key roles in the regulation of several physiological functions such as motor activity food intake but also development psychiatric disorders. Here we tested hypothesis, whether blockade 2C (5-HT2C) receptors prevents reduced locomotor other behavioral effects caused by a cannabinoid 1 (CB1) receptor antagonist. As pretreatment, administered SB-242084 (1 mg/kg, ip.), 5-HT2C antagonist or vehicle (VEH) followed treatment with AM-251 (5 10 CB1 VEH. two drugs alone co-administration were investigated social interaction (SI) elevated plus maze (EPM) tests male Wistar rats. Our results show that decreased time spent rearing SI test EPM test. In contrast, produced increased evoked anxiolytic-like effect both tests. When applied combination, these moderated SB-242084. Based on findings, conclude certain unwanted antagonists could be prevented pretreatment antagonists.