Bone Regeneration Potential of Biphasic Nanocalcium Phosphate with High Hydroxyapatite/Tricalcium Phosphate Ratios in Rabbit Calvarial Defects

• DOI: 10.11607/jomi.4531
• Publication Date: 2016-03-21T15:56:54Z
• Authors: Prisana Pripatnanont; Pongsakorn Praser...; Srisurang Suttapr...; Narit Leepong; Naruporn Monmatur...
• Keywords: X-ray microtomography; Bone Formation; Parietal bone; Densitometry

This study aimed to evaluate the effect of biphasic calcium phosphate (BCP) with high hydroxyapatite/tricalcium (HA/TCP) ratios on bone formation in rabbit calvarial defects.Sixteen New Zealand white rabbits were randomly divided into two groups, a control group and an experimental group. In each animal, bilateral circular defects (10-mm diameter) created calvarium. (three per time frame), grafted autogenous chips one side left empty other side. (five BCP1 (HA:TCP, 8:2) BCP2 9:1) contralateral The animals sacrificed at 2 8 weeks as designated. Bone residual grafting material assessed by radiographic densitometry, microcomputed tomography (micro-CT), histomorphometric analysis.Histologic observation revealed that BCP1, BCP2, preserved good contours defect, while unfilled defect showed connective tissue healing. Micro-CT analysis comparable percentages volume fraction (% BV/TV) (20.70% ± 2.76%) (20.72% 3.97%) times higher than (9.90% 0.75%, 10.57% 0.85%). had significantly (P < .005) greater % BV/TV (34.58% 8.85%) groups. percentage was not different. histomorphometry demonstrated increase newly formed from all (autogenous: 4.30% 0.76%, 12.83% 7.74%; unfilled: 2.82% 1.19%, 8.14% 6.35%; BCP1: 3.01% 2.57%, 8.81% 3.86%; BCP2: 3.24% 1.09%, 10.27% 3.98%).BCP ratio HA presented osteoconductive properties space-maintaining capacity would be beneficial for long-term preservation or when stable graft is essential.