Toll-Like Receptor-2 Modulates Ventricular Remodeling After Myocardial Infarction

• DOI: 10.1161/01.cir.0000101921.93016.1c
• Publication Date: 2003-12-02T01:23:19Z
• Authors: Tetsuro Shishido; Naoki Nozaki; Seiji Yamaguchi; Yoko Shibata; Joji Nitobe; Takuya Miyamoto; Hiroki Takahashi; Takanori Arimoto; Kunihiko Maeda; Mitsunori Yamakawa; Osamu Takeuchi; Shizuo Akira; Yasuchika Takeishi; Isao Kubota
• Keywords: Ventricular remodeling

Toll-like receptors (TLRs) are members of the interleukin-1 receptor family and transduce similar signals as in response to exogenous pathogens. Recent studies have demonstrated that TLRs activated by endogenous signals, such heat shock proteins oxidative stress, may contribute ventricular remodeling after myocardial infarction. In this study, we determined whether TLR-2 was involved cardiac infarction.Myocardial infarction induced surgical left anterior descending coronary artery ligation on wild-type (WT) mice TLR-2-knockout (KO) mice. The survival rate significantly higher KO than WT 4 weeks (65% versus 43%, P<0.03). Infarct size degree inflammatory cell infiltration infarct area were between However, fibrosis noninfarct much less (P<0.01) accompanied reduced transforming growth factor-beta1 collagen type 1 mRNA expressions (P<0.01 P<0.05, respectively). Left dimensions at end diastole smaller week (P<0.05) surgery. Furthermore, fractional shortening (27.7+/-2.5% 21.2+/-2.6%, week, 24.3+/-2.0% 16.6+/-2.5%, P<0.01, weeks) compared with mice.These data suggest plays an important role