Major Racial Differences in Coronary Constrictor Response Between Japanese and Caucasians With Recent Myocardial Infarction

• DOI: 10.1161/01.cir.101.10.1102
• Publication Date: 2012-06-12T00:42:29Z
• Authors: Christian Pristipino; John F. Beltrame; Maria L. Finocchiaro; Ryuichi Hattori; Masatoshi Fujita; Rocco Mongiardo; Domenico Cianflone; Tommaso Sanna; Shigetake Sasayama; Attilio Maseri
• Keywords: Male; Arteriosclerosis; Incidence; Angiography; Myocardial Infarction; 610; Coronary Vasospasm; Middle Aged; Acetylcholine; White People; 3. Good health; Vasomotor System; 03 medical and health sciences; 0302 clinical medicine; Asian People; Italy; Japan; Vasoconstriction; Humans; Female; Aged

Enhanced coronary vasomotion may contribute to acute occlusion during the phase of myocardial infarction (AMI). Japanese have a higher incidence variant angina than Caucasian patients, but racial differences in vasomotor reactivity early after AMI are controversial.The same team studied 15 and 19 patients within 14 days by acetylcholine injection into non-infarct-related (NIRA) infarct-related (IRA) arteries followed nitroglycerin. Incidence vasodilation, vasoconstriction, spasm, basal tone were assessed proximal, middle, distal segments each drug bolus quantitative angiography. had much lower cholesterol levels Caucasians (183+/-59 versus 247+/-53 mg/dL, P<0.006) showed vasodilation (2% 9% segments) greater spasm (47% 15% arteries, P<0.00001). was IRAs NIRAs both populations (67% 39% 23% 11%, respectively). Multivessel more common (64% 17%, P<0.02) vasoconstriction nonspastic (-23.4+/-14.9% -20.1+/-15.7%, presence similar average with respect post-nitroglycerin dilation nonsignificant atherosclerotic score.Soon AMI, exhibited 3-fold-greater Caucasians. The causes such warrant further investigation because they relevant pathophysiological therapeutic implications.