Endothelial Dysfunction in Men With Small LDL Particles

• DOI: 10.1161/01.cir.102.7.716
• Publication Date: 2012-06-12T00:42:29Z
• Authors: Juha Vakkilainen; Sari Mäkimattila; Anneli Seppälä-...; Satu Vehkavaara; Sanni Lahdenperä; Per-Henrik Groop; Marja-Riitta Task...; Hannele Yki-Järv...
• Keywords: Sodium nitroprusside; Endothelial Dysfunction

Background —It is unknown whether LDL particle size is, independent of other lipids and lipoproteins, associated with endothelial dysfunction in vivo. Methods Results —We determined vivo function 34 healthy men by measuring forearm blood flow responses to intrabrachial artery infusions acetylcholine (ACh, an endothelium-dependent vasodilator) sodium nitroprusside (an endothelium-independent vasodilator). peak was measured gradient gel electrophoresis. Men small particles (LDL diameter ≤25.5 nm, n=10) had a 39% lower response ACh than large >25.5 n=24, 6.9±3.6 versus 11.4±5.1 mL/dL · min, P =0.006). The groups comparable cholesterol concentrations (3.9±0.6 3.7±1.0 mmol/L, particles), pressure, glucose concentrations, body mass indexes. ( r =0.45, =0.01) but not HDL =0.31, =0.09) or triglycerides =−0.19, =0.30) significantly correlated vasodilation. Serum triglyceride were inversely =−0.44, =0.01). In multivariate regression analysis, the only significant determinant ACh-induced increase flow. Sodium nitroprusside–stimulated vasodilation similar both groups. Conclusions —Small are impaired concentrations. may therefore mediate adverse effects hypertriglyceridemia on vascular function.