An Analysis of Segmental Ischemic Dysfunction Utilizing the Pressure-Length Loop

• DOI: 10.1161/01.cir.49.4.748
• Publication Date: 2012-06-11T23:56:43Z
• Authors: JOHN V. TYBERG; JAMES S. FORRESTER; H. L. WYATT; STEVEN J. GOLDNER; WILLIAM W. PARMLEY; H. J. C. SWAN
• Keywords: Systole; Cardiac cycle

Left ventricular (LV) pressure and myocardial segment length, determined by an epicardial mercury-in-silastic length gauge, were plotted simultaneously to obtain a pressure-length loop before after left anterior descending artery (LAD) occlusion in 11 dogs. Previous studies have indicated that the area within this is sensitive reproducible means of quantitating regional performance. Immediately following ligation, systolic performance deteriorated as progressive reduction area. Within approximately 30 sec zero for was observed, indicating no effective work being performed ischemic segment. During ensuing 3-5 min moved into clockwise orientation which done on rather than The magnitude 50% amount previously generated In addition, during latter period repetitive passive stretch, end-diastolic relationship shifted right increased diastolic compliance. Restoration perfusion produced variable results. Substantial return function observed two animals, but recovery majority animals limited elimination paradoxical expansion without restoration active contraction. Therefore, method allows quantitation performance, indicates predictable pattern significant changes both systole diastole accompanies acute ischemia.