Intravenous short-term infusion of streptokinase in acute myocardial infarction.

• DOI: 10.1161/01.cir.67.3.536
• Publication Date: 2011-06-17T20:29:13Z
• Authors: R Schröder; G Biamino; E R von Leitner; T Linderer; T Brüggemann; J Heitz; H F Vöhringer; K Wegscheider
• Keywords: Coronary arteries

Short-term i.v. infusion of streptokinase was performed in 93 patients within 6 hours after the onset acute myocardial infarction. Twenty-six underwent angiography phase (group A) and 52 fourth week only B); 15 had no angiography. Seven died during hospital stay six suffered nonfatal reinfarctions. There were bleeding complications. In 11 21 group A patients, occluded coronary arteries opened 1 hour started. 84% groups B, infarct-related artery patent week. 75% arteries, residual luminal diameter stenosis less than 70%. According to serial serum CK-MB curves, recanalization achieved mostly 1-2 hours. Myocardial salvage indicated by improvement local contraction disorders recanalized significant relationship between infarct size time from symptom treatment B. These data suggest that a high-dose, short-term, is safe efficient method restoring blood flow. Expeditious initiation critical determinant for early myocardium. Patients with thrombotically subtotal occlusion probably receive most benefit. Evaluation true impact on survival function will require controlled clinical trials.