Influence of atrial systole on the Frank-Starling relation and the end-diastolic pressure-diameter relation of the left ventricle.

• DOI: 10.1161/01.cir.67.5.1045
• Publication Date: 2011-06-17T20:29:13Z
• Authors: T Linderer; K Chatterjee; W W Parmley; R E Sievers; S A Glantz; J V Tyberg
• Keywords: End-systolic volume; End-diastolic volume; Systole

The influence of atrial systole on the left ventricular function curve (stroke volume vs end-diastolic pressure or diameter) and diameter relation was studied in nine anesthetized, open-chest dogs whose atrioventricular (AV) node had been completely blocked. Measurements were made during loading with pericardium closed opened alternate AV sequential pacing (to permit contribution to filling) simultaneous prevent contribution). When closed, withdrawal shifted stroke-volume downward, but did not shift stroke volume-end-diastolic relation, i.e., it reduced for a given according reduction volume. downward caused by an upward pressure-diameter which, pressure, resulted smaller and, thus, reason that atrium remained full thus increased pericardial increasing Opening right, abolished effect these curves. We conclude presence intact pericardium, shifts because improves performance preload.