Incomplete lysis of thrombus in the moderate underlying atherosclerotic lesion during intracoronary infusion of streptokinase for acute myocardial infarction: quantitative angiographic observations.

• DOI: 10.1161/01.cir.73.4.653
• Publication Date: 2011-06-17T20:29:13Z
• Authors: B G Brown; C A Gallery; R S Badger; J W Kennedy; D Mathey; E L Bolson; H T Dodge
• Keywords: Lumen (anatomy)

Thrombolytic recanalization of the obstructed coronary lumen was studied in 32 patients receiving intracoronary streptokinase for 60 to 90 min during acute myocardial infarction. The process viewed at high arteriographic magnification and quantified with computer-assisted measurements from repeated single-plane views. variability method this application 0.15 0.18 mm on minimum diameter estimates. Structural details were seen that are not commonly appreciated conventional magnification. recanalized appears form along an interface between thrombus vessel wall, progressively enlarging its 0.65 +/- 0.24 (+/- 1 SD) end short-term infusion reflecting a final percent stenosis 77 10%. In nine infarct lesions found patent 5 3 weeks later, further improved average 0.34 (p less than .005) 13% .01). A thin film contrast medium surrounding obstructing faintly defined boundaries original atherosclerotic all but two cases. "original stenosis" measured 1.25 0.32 56 14% when first visualized; it unchanged throughout course streptokinase. five catheterized 10 12 before their infarction, averaged 1.15 0.22 preinfarct angiogram, as compared 1.17 0.23 thrombolytic therapy = NS). cases, lesion 50% stenosis, 21 cases 60%.(ABSTRACT TRUNCATED AT 250 WORDS)